Author:
Han Sen,Zhang Ting,Kusumanchi Praveen,Huda Nazmul,Jiang Yanchao,Yang Zhihong,Liangpunsakul Suthat
Abstract
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
Funder
National Institutes of Health
Indiana University
Indiana Clinical and Translational Sciences Institute
Indiana Institute for Medical Research
Publisher
The Korean Association for the Study of the Liver
Subject
Molecular Biology,Hepatology
Cited by
12 articles.
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