Peptic ulcer candidate genes-Reference-Cited by-同舟云学术

Peptic ulcer candidate genes

Published:2021-04-07 Issue:2 Volume: Page:52-57
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Rashina O. V.¹,Churnosov M. I.¹

Affiliation:

1. Belgorod National Research University

Abstract

Hereditary predisposition is one of the aetiopathogenetic factors in the development of gastric ulcer and duodenal ulcer. The analysis of literature materials allows us to identify a number of candidate genes that play a role in the formation of peptic ulcer: PSCA, ABO, IL1β, IL1RN, TNFα, HSP70-1, GSR, TLR4, TLR2, TLR9, MMP-1, MMP-3, MMP- 9, TIMP-3, PGC, MIF, MPO, COX-1. Considering that most of the studies were carried out abroad, the results differ depending on the ethnic characteristics of the studied groups, sometimes they are contradictory, and the works of domestic scientists on this problem are rare, further study of the role of polymorphic variants of candidate genes in the formation of gastric ulcer and duodenal ulcer is necessary.

Publisher

LLC Global Media Technology

Subject

General Medicine

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