Systematic computer analysis of ornithine research to identify the most promising trends in therapeutic use - focus on liver function-Reference-Cited by-同舟云学术

Systematic computer analysis of ornithine research to identify the most promising trends in therapeutic use - focus on liver function

Published:2021-09-27 Issue:7 Volume: Page:30-36
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Gromova O. A.¹^ORCID,Torshin I. Yu.¹^ORCID,Lazebnik L. B.²^ORCID,Maksimov V. A.³^ORCID

Affiliation:

1. Federal Research Center “Informatics and Management” of the Russian Academy of Sciences, Institute of Pharmacoinformatics

2. Federal State Budgetary Educational Institution of Higher Education “A. I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russion Federation

3. FGBOU DPO RMAPO Ministry of Health of Russia

Abstract

This analysis of 21,626 publications on fundamental and clinical studies of ornithine showed that the pharmacological effects of ornithine are due to its participation in the neutralization of ammonia in the urea cycle, amino acid metabolism, intracellular protein synthesis, inflammation and the functioning of T-cell immunity. The use of ornithine is promising for hyperammonemia, steatohepatosis and other liver pathologies, hepatic encephalopathy and sarcopenia. Ornithine maintains hormonal balance by promoting the production of insulin and growth hormone.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

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