Effect of l-ornithine-l-aspartate therapy on the hyperammonemia level and results of the number connection test of patients suffering from nonalcoholic fatty liver disease-Reference-Cited by-同舟云学术

Effect of l-ornithine-l-aspartate therapy on the hyperammonemia level and results of the number connection test of patients suffering from nonalcoholic fatty liver disease

Published:2020-03-24 Issue:9 Volume: Page:80-84
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Kizova E. A.¹,Potekhina Yu. P.²^ORCID

Affiliation:

1. City Clinical Hospital № 13 of Avtozavodsky region of Nizhny Novgorod

2. Privolzhsky research medical university

Abstract

The aim was to study the hyperammonemia level and the duration of implementation of the number connection test (NCT) for patients with nonalcoholic fatty liver disease (NAFLD) in the pre-cirrhosis stage, including effect of the oral administration of L-ornithine-L-aspartate (LOLA) on these indices, and NCT correlation with body chemistry values. Material and methods: the research covered 103 patients with NAFLD to study the hyperammonemia level and other relevant blood chemistry values; we performed NCT before and after the LOLA treatment. The aim was to study the hyperammonemia level and the duration of implementation of the number connection test (NCT) for patients with nonalcoholic fatty liver disease (NAFLD) in the pre-cirrhosis stage, including effect of the oral administration of L-ornithine-L-aspartate (LOLA) on these indices, and NCT correlation with body chemistry values. Material and methods: the research covered 103 patients with NAFLD to study the hyperammonemia level and other relevant blood chemistry values; we performed NCT before and after the LOLA treatment.

Publisher

LLC Global Media Technology

Subject

General Medicine

Reference15 articles.

1. Levitt D.G., Levitt M. D. A model of blood- ammonia homeostasis based on a quantitative analysis of nitrogen metabolism in the multiple organs involved in the production, catabolism, and excretion of ammoniain in humans. Clin Exp Gastroenterol. 2018, № 11, pp. 193–215.

2. Damink S.W., Jalan R., Redhead D. N., et al. Interorgan ammonia and amino- acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology. 2002, Vol. 36, № 5, pp. 1163–1171.

3. Plotnikova E. Yu., Sukhikh A. S. Different types of hyperammonemia in clinical practice. Meditsinsky sovet (Medical Council). Gastroenterology. 2018, №14, pp. 34–42. (in Russ.)

4. Ageyeva Ye. A., Alekseyenko S. A. Application of the oral “L-ornithine-L-aspartate” at hyperammoniemia at chronic liver diseases at precirrhotic stage. Clinical prospects of gastroenterology, gepatology. 2015, №6, pp. 24–26. (In Russ.)

5. Jalan R., DeChiara F., Balasubramaniyan V., et al. Ammonia produces pathological changes in human hepatic stellate cell sand is target for therapy of portal hypertension. J. Hepatology. 2016, Vol.64, № 4, pp. 823–833.

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mild post-COVID syndrome in young patients;Terapevticheskii arkhiv;2023-10-11

2. Russian Consensus on “Hyperammonemia in Adults”: The 2021 Version (in English);Experimental and Clinical Gastroenterology;2022-01-16

3. Russian Consensus “Hyperammonemia in Adults” (Version 2021);Experimental and Clinical Gastroenterology;2021-05-22

4. Fatigue and ammonia levels of capillary blood in medical students;Experimental and Clinical Gastroenterology;2020-06-25