Affiliation:
1. Izhevsk State Medical Academy of the Ministry of Health of the Russian Federation
Abstract
Objective. To study the state of the enteral parietal microbiota and to assess the conjugacy of its changes with motor-evacuation disorder of the gastrointestinal tract (gastrointestinal tract) in chronic duodenal insufficiency.Materials and methods. The study included 40 patients with chronic duodenal insufficiency (CDN). Of these, 21 (52.5%) were women, 19 (47.5%) were men, the average age was 37.1± 13.8 years. CDN was diagnosed using anamnestic and physical data, X-ray and endoscopic examinations, intracavitary manometry. Enzyme immunoassay determined vitamin B12, 25-OH Vitamin D, transferrin. The study of the motor function of the gastrointestinal tract was carried out using the gastroenteromonitor “Gastroscan-GEM”. The method of gas chromatography with mass spectrometry was used to study the enteral wall microbiota.The results of the study. The blood showed a decrease in fat-soluble vitamins B12 and 25-OH vitamin D in relation to control. There was a decrease in the transferrin saturation coefficient (13.2%) compared to the control group (34.7%, p=0.04). Gastroenteromonitoring on the device “Gastroscan-GEM” showed a decrease in the coefficients of rhythmicity in the stomach and DPC in the fasting and postprandial periods. Chromass spectrometric analysis of resident microflora in patients with CDN revealed a significant decrease in Lactobacillus spp 1245.3± 0.21 cl/g x 10^3 and Bifidobacterium spp 1453.2± 0.18cl/g x 10^3 against the background of pronounced growth of bacteria of the genus Clostridium, Eggerthella lenta 412.3± 0.84cl/g x 10^3, Propionibacterium acnes 58.6± 0.32cl /g x 10^3, Propionibacterium freudenreichii 2388.7± 0.62 cl/g x 10^3, Propionibacterium jenseni 146.6±0.32 cl/g x 10^3, Staphylococcus spp 658.4± 0.28 cl/g x 10^3, Streptococcus mutans (anaerobic) 494.3±0.74 cl/g x 10^3, Streptomyces spp. 305.3±0.26 cl/g x 10^3. It was shown that the increased growth of pathogenic microflora was associated with a violation of the rhythm of duodenal motility.Conclusion. In patients with chronic duodenal insufficiency, a pronounced growth of parietal pathogenic microflora was detected, depending on the state of motor activity of the duodenum.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
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