Affiliation:
1. Ural State Medical University of the Ministry of Health of Russia
Abstract
The aim is to study the effect of Helicobacter pylori infection on risk of developing gastroesophageal reflux disease. Materials and methods - cross-sectional observational study of 1007 patients with dyspepsia syndrome who underwent videoesophagogastroduodenoscopy with biopsy and histological examination of biopsy specimens of the gastric mucosa by OLGA-system. The age, gender, overweight, cigarette smoking, presence of Helicobacter pylori infection and gastritis stage were assessed. Results - the study showed a significant decrease in the incidence of gastroesophageal reflux disease in patients with positive H. Pylori status by 4% (RR 0,68; 95% CI, 0.49-0.94, p=0,041). The risk of developing gastroesophageal reflux disease significantly higher in overweight (RR 2,62; 95% CI 2,0-3,56; р<0,001) men (RR 1,76; 95% CI 1,33-2,32; р=0,0046) who smoked cigarettes (RR 3,23; 95% CI 2,45-4,24; р<0,001) and was not associated with the patient’s age and the stage of gastritis (р>0,05). Conclusion - a significant reduction in the frequency and risk of developing gastroesophageal reflux disease in patients with Helicobacter pylori infection is demonstrated.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
Reference26 articles.
1. Ivashkin V. T., Maev I. V., Trukhmanov A. S., et al. Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(4):70-97. (In Russ.) doi: 10.22416/1382-4376-2020-30-4-70-97.
2. Pace F., Pallotta S., Casalini S., Porro G. B. A review of rabeprazole in the treatment of acid-related diseases. Ther Clin Risk Manag. 2007 Jun;3(3):363-79. PMID: 18488081; PMCID: PMC2386363.
3. Smith C. D. Surgical therapy for gastroesophageal reflux disease: indication, evaluation, and procedures. Gastrointestinal Endoscopy Clinics of North America. 2009; 19(1): 35-48. doi: 10.1016/j.giec.2008.12.007.
4. Maev I. V., Balashova N. N. Sovremennye aspekty terapii gastroézofageal’noĭ refliuksnoĭ bolezni [Modern aspects of treating gastroesophageal reflux disease]. Eksp Klin Gastroenterol. 2003;(1):5-11, 181. Russian. PMID: 12664775.
5. Stanghellini V., Cogliandro R., Cogliandro L. et al. Unsolved problems in the management of patients with gastro-esophageal reflux disease. Digestive and Liver Disease, 2002; 34: 843-8. doi:10.1016/j.dld.2003.09.003.