Affiliation:
1. Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University, Ministry of Healthcare of the Russian Federation (Sechenov University)
Abstract
The development of gastroenteritis caused by non-typhoidal Salmonella (NTS) is mediated by the action of effectors that belong to the Type three secretory systems (T3SS) of Salmonella enterica. These effectors are expressed by Salmonella pathogenicity islands 1 and 2 located in the genome. The effectors of T3SS-1 provide invasion of salmonella into host cell, take part in the development of inflammatory diarrhea some and may act as a predisposing factor in oncogenesis leading to the development of colorectal cancer (CRC). The T3SS-2 effectors provide intracellular survival of bacteria in the host cell and evading from the host adaptive immune response that may lead to the prolonged persistence.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
Reference33 articles.
1. Ohad Gal-Mor. Persistent Infection and Long-Term Carriage of Typhoidal and Nontyphoidal Salmonellae. Clinical Microbiology Review. 2019 Jan; 32(1): e00088-18. Published online Nov 28. doi:10.1128/CMR.00088-18
2. Rana S., Maurya S., Chadrasekhar H., Srikanth C. V. Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects. Mol Aspects Med. 2021;81:100997. doi:10.1016/j.mam.2021.100997
3. Jeffrey D Stanaway. The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infec. Dis. 2019 Dec;19(12):1312-1324. doi:10.1016/S1373-3099(19)30418-9
4. Boichenko M. N., Bosh’ian R.E., Kravtsova E. O., Budanova E. V. About the role of causative agent of typhoid fever in the development of gallbladder cancer. Experimental and Clinical Gastroenterology. 2020;(6):154-157. (In Russ.) doi:10.31146/1682-8658-ecg-178-6-154-157 @@Boichenko M. N., Bosh'yan R. E., Kravtsova E. O., Budanova E. V. O roli vozbuditelya bryushnogo tifa v razvitii raka zhelchnogo puzyrya. Eksperimental'naya i klinicheskaya gastroenterologiya. 2020.178(6): 154-157. doi:10.31146/1682-8658-ecg-178-6-154-157
5. Stanaway J.D., Parisi A., Sarkar K., Blacker B. F., et al. The global burden of non-typhoidal salmonella invasive disease: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect. Dis. 2019, 19: 1312-1324. doi:10.1016/S14473-3099(19)30418-9