Genetic features of pathogenesis in pancreatic adenocarcinomas

Abstract

To date, the problem of pancreatic cancer is the high mortality rate. The IARC predicts that pancreatic cancer will become the second leading cause of cancer deaths by 2030. Because patients usually present with advanced disease and respond poorly to broad-spectrum chemotherapy, overall survival is only 10%. This highlights the urgent clinical need to identify new therapeutic approaches for patients with pancreatic adeno-carcinoma. Objective: To identify patterns of genetic changes in the development of pancreatic carcinoma and to consider pathogenesis of this process. Materials and methods: data from multi-genetic panels of Memorial Sloan Kettering Cancer Center, articles of the journal Cancers, and PubMed re-source articles. Results: the work has uncovered major and alternative pathways in the pathogenesis of pancreatic cancer, established hypotheses of similar pathways in tumors of other localizations and the presence of fundamental pathogenetic links in pathogenesis, indicating the universality of certain genetic changes in tumor growth.