Seasonal fluctuations in vitamin D levels in children with various diseases

Abstract

The main problem of research on vitamin D sufficiency is the lack of an integrated approach, that is, a dynamic assessment of 25(OH)D throughout the entire period of childhood and in different seasons of the year. This is necessary to highlight those specific diseases in which priority targeted prevention and therapy of hypovitaminosis will be indicated, taking into account the numerous biological and pathophysiological effects of vitamin D metabolites, in particular, 25(OH)D, which have socially significant clinical consequences. The aim of the study: to assess the level of 25(OH)D in children with various diseases living in Moscow and the Moscow region, taking into account the season of the year and age. Materials and methods. A study was made of the availability of 25(OH)D among 1501 children living in Moscow and the Moscow regions. Discussion. A high frequency of severe vitamin D deficiency was found among children with oncological diseases (41.7%), diseases of the nervous system (12.9) and blood system (10.9). It was shown that 25.0% of children with cerebral palsy, 19.4% of children with chronic kidney disease, 16.7% with type 1 diabetes mellitus, 15.5% with juvenile idiopathic arthritis have a pronounced deficiency of 25(OH)D, 14.8% of patients with anemia, 10.3% with inflammatory bowel disease, 7.9% of children born prematurely. Conclusion. Severe and year-round disorders of 25(OH)D metabolism were noted in children suffering from autoimmune (type 1 diabetes mellitus, inflammatory bowel disease, idiopathic juvenile arthritis), oncological diseases, cerebral palsy, prematurity, and chronic kidney disease.