Small gut intestine microbiota in adolescent girls with obesity-Reference-Cited by-同舟云学术

Small gut intestine microbiota in adolescent girls with obesity

Published:2024-03-07 Issue:7 Volume: Page:34-41
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Evdokimova N. V.¹^ORCID,Shogiradze L. D.²^ORCID,Pokhlebkina A. A.³^ORCID,Petrenko Yu. V.¹^ORCID,Mikhnina E. A.⁴^ORCID,Novikova V. P.¹^ORCID,Bezhenar V. F.⁵^ORCID

Affiliation:

1. St. Petersburg State Pediatric Medical University

2. Children’s City Clinic No. 19

3. Scandinavia Clinic in St Petersburg

4. Pavlov First Saint Petersburg State Medical University; D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology

5. Pavlov First Saint Petersburg State Medical University

Abstract

Aim. To characterize the small intestine microbiome in adolescent girls with obesity according to gas chromatography-mass spectrometry of microbial markers (CMSMM). Material and Methods. The research involved 72 adolescents (girls) 12-17 years old, half of the children (group 1) were obese, the other half (group 2) were not obese, as well as did not have any chronic diseases. Microbial markers in blood samples were examined by the CMSMM method. In order to examine correlation between the small intestine microbiota and obesity, a logistic model was formed. ROC analysis was used to determine possible effects of microorganisms on obesity. Results. There were found significant differences in the small intestine microbiome of obese girls, and alike microbiocenosis of children with normal body weight. Obese adolescent girls had higher levels of Nocardia asteroides 504.14[296; 1015] cells/g×10⁵ and Candida spp 241.85[198.09;629.97] cells/g×10⁵. Microorganisms of the opportunistic flora such as Actinobacteria, Firmicutes, Proteobacteria and microscopic fungi, as well as herpesviruses were significantly deficient. Conclusions. Nocardia asteroides and Candida spp. are associated with obesity. The risk of obesity in adolescent girls increases with a growing number of above-mentioned microorganisms.

Publisher

LLC Global Media Technology

Reference14 articles.

1. Kohut T., Robbins J., Panganiban J. Update on childhood/adolescent obesity and its sequela. Curr Opin Pediatr. 2019;31(5):645-653. doi: 10.1097/MOP.0000000000000786

2. Novikova V.P., Gurova M. M. [Multidisciplinary problems of obesity in children]. St. Petersburg. SpecLit, 2018, 582 p. (In Russ.)@@ Mul'tidistsiplinarnye problemy ozhireniya u detei / pod red. V. P. Novikovoi, M. M. Gurovoi. - Sankt-Peterburg: SpetsLit, 2018. - 582 s.

3. Gritsinskaya V. L., Novikova V. P., Khavkin A. I. On the issue of the epidemiology of obesity in children and adolescents (a systematic review and meta-analysis of scientific publications over a 15-year period). Questions of practical pediatrics. 2022; 17(2): 126-135. (In Russ.) doi: 10.20953/1817-7646-2022-2-126-135.@@ Gritsinskaya V. L., Novikova V. P., Khavkin A. I. K voprosu ob epidemiologii ozhireniya u detei i podrostkov (sistematicheskii obzor i meta-analiz nauchnykh publikatsii za 15-letnii period). Voprosy prakticheskoi pediatrii. 2022; 17(2): 126-135. doi: 10.20953/1817-7646-2022-2-126-135.

4. Milner E. B., Evdokimova N. V., Novikova V. P., Khavkin A. I. Cardiovascular risks of adolescent obesity. Questions of practical pediatrics. 2022; 17(5): 83-89. (In Russ.) doi: 10.20953/1817-7646-2022-5-83-89.@@ Mil'ner E. B., Evdokimova N. V., Novikova V. P., Khavkin A. I. Kardiovaskulyarnye riski podrostkovogo ozhireniya. Voprosy prakticheskoi pediatrii. 2022; 17(5): 83-89. doi: 10.20953/1817-7646-2022-5-83-89.

5. Shaban Mohamed M. A., AbouKhatwa M.M., Saifullah A. A., Hareez Syahmi M., Mosaad M., Elrggal M. E., Dehele I. S., Elnaem M. H. Risk Factors, Clinical Consequences, Prevention, and Treatment of Childhood Obesity. Children (Basel). 2022;9(12):1975. doi: 10.3390/children9121975.