Autoimmune gastritis and stomach cancer: assessing the risks

Author:

Gubanova A. V.1ORCID,Livzan M. A.2ORCID,Krolevets T. S.2ORCID,Mozgovoi S. I.2ORCID,Rubtsov A. V.2ORCID,Stepanchenko M. A.2ORCID

Affiliation:

1. City polyclinic No.8; Omsk State Medical University

2. Omsk State Medical University

Abstract

The purpose of this publication is to systematize available data on the risks of developing stomach cancer in patients with a chronic autoimmune gastritis with a demonstration of the clinical case of a patient with a chronic autoimmune gastritis and a neuroendocrine gastric tumor of the type 1. Discussion: the article discusses the risks of stomach cancer in patients with chronic autoimmune gastritis. A mechanism for the formation of a neuroendocrine gastric tumor of the type 1, associated with autoimmune gastritis, is given. A clinical example of a patient with a long history of dyspepsia, the presence of concomitant changes in the results of laboratory tests, describes an algorithm for diagnosis of autoimmune gastritis and associated neuroendocrine tumors. The risks of the development in patients with autoimmune gastritis of formidable complications as an adenocarcinoma of the stomach are considered. Conclusion: Chronic autoimmune gastritis is a precancerous diseases of the stomach, with the progressive atrophy of the gastric body mucosa, and associated with an increased risk of developing neuroendocrine gastric tumor of the type 1 and adenocarcinoma of the stomach. Patients with autoimmune gastritis need dynamic outpatient observation, with endoscopic control and assessment of the degree and stage of gastritis in OLGA system, with immunogistochemistry to evaluate the risks of stomach cancer and timely implementation of the necessary measures of carcinoprection.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

Reference32 articles.

1. Gomceli I, Demiriz B, Tez M. Gastric carcinogenesis. World J Gastroenterol 2012; 18(37): 5164-5170. doi: 10.3748/wjg.v18.i37.5164.

2. Losik Ye.A., Ivashkin V. T. Autoimmune gastritis: pathogenesis and risk factors for malignant transformation.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015;25(5):81-5 (In Rus.).@@ Losik E. A., Ivashkin V. T. Patogenez autoimmunnogo gastrita i faktory riska zlokachestvennoi neoplazii zheludka. Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2015;25(5): 81-5.

3. Hemminki K, Liu X, Ji J, Sundquist J, Sundquist K. Autoimmune disease and subsequent digestive tract cancer by histology. Ann Oncol. 2012 Apr; 23 (4): 927-33. doi: 10.1093/annonc/mdr333.

4. Cavalcoli F, Zilli A, Conte D, Massironi S. Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. World J Gastroenterol. 2017 Jan 28;23(4): 563-572. doi: 10.3748/wjg.v23.i4.563.

5. Toh B. H. Diagnosis and classification of autoimmune gastritis. Autoimmun Rev. 2014 Apr-May; 13 (4-5): 459-62. doi: 10.1016/j.autrev.2014.01.048.

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