Affiliation:
1. Perm State Medical University n. a. E. A. Wagner of the Ministry of Health of the Russian Federation
Abstract
This review consolidates the data of recent Russian and foreign research works, considering how gut microbiota composition and gut metabolites can affect metabolic disorders. From the standpoint of modern concepts, the authors discuss the functions of the immune system responsible for maintaining relationships with symbiotic microorganisms, analyze the accumulated information on the participation of metabolites of gut microflora in the development of pathological conditions. According to the results of the last two decades achieved, challenges ahead include translation of findings and mechanisms into clinical practice and development of therapeutic options and regimens that target metabolic risks by modulation of gut microbes and metabolites.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
Reference51 articles.
1. Popova E.N., Gordeev I. G. Sovremennye predstavlenija o mikrobiote cheloveka // E. L. Nikonov, E. N. Popova. edd. Mikrobiota. 2019. 7-19. (In Russ.)@@ Popova E. N., Gordeev I. G. Sovremennye predstavleniya o mikrobiote cheloveka // Monografiya pod redaktsiei E. L. Nikonova i E. N. Popovoi. Mikrobiota. - 2019. - S. 7-19.
2. Hawrelak J. A., Myers S. P. The causes of intestinal dysbiosis: a review. Alternative Medicine Review. 2004 Jun;9(2):180-97. PMID: 15253677.
3. Sekirov I., Russell S. L., Antunes L. C., Finlay B. B. Gut microbiota in health and disease. Physiological Reviews. 2010 Jul;90(3):859-904. doi: 10.1152/physrev.00045.2009.
4. Eberl G. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunology. 2010 Sep;3(5):450-60. doi: 10.1038/mi.2010.20.
5. Al-Assal K., Martinez A. C., Torrinhas R. S., et al. Gut microbiota and obesity. Clinical Nutrition Experimental. 2018; 20:60-64. doi: 10.1016/j.yclnex.2018.03.001.