Features of the course of liver cirrhosis in the background of infection with COVID-19

Abstract

Purpose of research. The study of the statistical and clinical features of liver cirrhosis (LC) against the background of a coronavirus infection caused by the SARS-CoV-2 virus. Materials and methods. 98 patients (51 men and 47 women) aged 23 to 69 years (mean age 53.8±1.9 years) with a verified diagnosis of cirrhosis were examined. The patients were divided into 2 groups. Group 1 consisted of 49 patients who underwent surgery in 2020-2021. coronavirus infection. The 2nd group also included 49 patients with cirrhosis who underwent treatment and examination in 2017-2018, which made it possible to exclude infection caused by the SARS-CoV-2 virus in them. Both groups were divided into 2 subgroups: recovered and deceased. A comprehensive statistical processing was carried out. Results. In the subgroups of recovered patients, the results in the dynamics of treatment were positive. The dynamics of liver function indicators in deceased patients of the 1st and 2nd groups also turned out to be similar, but negative. The analysis of cytolysis indicators established their significant progression and more significant in the 1st group. Alkaline phosphatase and gammaglutamyltransferase had the same dynamics, which indicated the progression of cholestasis syndrome. Violations of bilirubin metabolism worsened and also significantly significantly in the 1st group. Worsened protein metabolism. Hemostasis indicators worsened in patients of the 1st group. As expected, the level of C-reactive protein was higher in patients of the 1st group, which was due to a specific inflammatory process of the respiratory organs. Conclusion. Our observations allow us to state that patients with cirrhosis have certain features of the course of the disease against the background of COVID-19 infection, namely, higher rates of liver function decompensation and death when infected with the SORS-CoV-2 virus.