Comparative analysis of microbiome indicators in patients with mental disorders and in healthy volunteers

Abstract

The state of human microbiome is closely related to higher nervous activity. Studies of the relationship between the state of the microbiome and the formation of neuropsychiatric disorders represent a very promising field of research. This work presents the results of a comparative analysis of the profiles of microbiome indicators in 36 ± 12-year-old patients with mental and behavioral disorders (n = 30) and in healthy volunteers (n = 10). The profiles of microbiome indicators were measured on the basis of blood analysis by mass chromatospectrometry. Numerous significant differences were found in microbiome patterns between patients and controls. On the basis of the established differences, two point scales were proposed and verified, which can be regarded as a kind of indices of “psychopathogenicity of the microbiome”. These scales make it possible not only to distinguish patients from controls, but also to rank the subjects according to the degree of “psychopathogenicity” of the microbiome profile.