Affiliation:
1. Saratov State Medical University named after V. I. Razumovskyy
Abstract
The study aimed to determine the presence of a relationship between prenatal exposure to potential risk factors and the development of necrotizing enterocolitis (NEC) in premature infants. Materials and Methods: The clinical data of 99 mother-newborn couples diagnosed with Bell’s stage IIA NEC and a comparable comparison group were studied. The clinical characteristics of the main group with NEC were compared with the control group using the Student’s t-test. To assess the severity of the impact of potential risk factors, the Cochran - Mantel - Hensel method was used with the construction of a logistic regression model. Results. A statistically significant relationship was established between ampicillin prescribed to pregnant women and the occurrence of NEC in newborns. The adjusted odds ratio (OR) of prenatal ampicillin exposure was significantly greater for infants with NEC (OR 2.3, 95% CI 1.1, 4.8, P = 0.003) than for infants in the comparison group. Potential influencing factors (arterial hypertension, chorioamnionitis, artificial feeding and male sex) which also contribute to the development of NEC in newborns during prenatal antibiotic therapy, have been identified.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
Reference26 articles.
1. Henry M.C., Moss R. L. Neonatal necrotizing enterocolitis. Semin Pediatr Surg. 2008 May;17(2):98-109. doi: 10.1053/j.sempedsurg.2008.02.005.
2. Luig M., Lui K.; NSW & ACT NICUS Group. Epidemiology of necrotizing enterocolitis - Part II: Risks and susceptibility of premature infants during the surfactant era: a regional study. J Paediatr Child Health. 2005 Apr;41(4):174-9. doi: 10.1111/j.1440-1754.2005.00583.x.
3. Kucherov Yu.I., Zhirkova Yu.V., Shishkina T. N., Mikhalev I. A., Arsa A. V., Chebotaeva L. I. Necrotizing enterocolitis in premature infants: Diagnosis and treatment. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(6):18-24. (In Russ.) @@Kucherov Yu. I., Zhirkova Yu. V., Shishkina T. N., Mikhalev I. A., Arsa A. V., Chebotaeva L. I. Diagnostika i lechenie nekroticheskogo enterokolita u nedonoshennykh. Rossiiskii vestnik perinatologii i pediatrii. 2014;59(6):18-24.
4. Lin PW, Nasr TR, Stoll BJ. Necrotizing enterocolitis: recent scientific advances in pathophysiology and prevention. Semin Perinatol. 2008 Apr;32(2):70-82. doi: 10.1053/j.semperi.2008.01.004.
5. Lin P.W., Stoll B. J. Necrotising enterocolitis. Lancet. 2006 Oct 7;368(9543):1271-83. doi: 10.1016/S0140-6736(06)69525-1.