Interaction of SARS-CoV-2 with gut microbiota

Abstract

To determine the influence of the gut microbiota to the severity and development of complications during COVID-19. Consider the importance of taking pro- pre- and metabiotics in increasing the body’s resistance to viral infections. Recently, much attention has been paid to the influence of the gutl microbiota on the course of many internal diseases of an infectious and non-infectious nature. The pathogenetic influence of changes in the gut microbita on the initiation and maintenance of the inflammatory response of the body, as well as the immune response, has been proven. A number of studies have noted a direct correlation between the increased susceptibility of the human gut microbiota to a new coronavirus infection and the occurrence of complications from the respiratory system. Microbiome’s changes lead to increase gut permeability, weak protective barrier and immune mechanisms of the gastrointestinal mucosa, lead to easier and faster penetration of the SARS-CoV-2 virus into the blood stream, followed by dissemination and damage to the lungs. In light of the available data, a close relationship between the severity of the novel coronavirus infection and the composition of the gut microbiota is highly likely. The article presents the results of some studies, on the basis of which it can be concluded about gut microbiota changes in COVID-19 patient and efficiency of pro-, pre- and metabiotics, including strains of Lactobacilli and antimicrobial peptides (AMP), in the treatment of patients with COVID-19 in order to improve prognosis and prevent complications. The information presented can be useful for those who are faced with the effect of the virus on the gastrointestinal tract and respiratory system and for those who, for preventive purposes, want to increase the resistance of their body.