HPgV infection and cryptogenic hepatitis: clinical observation

Abstract

The causative agent of HPgV infection (HGV, GBV-C) was first described as hepatitis G virus, which was not confirmed during further researches. Human pegivirus-1 cannot be the cause of hepatitis and is not even pathogenic. The article presents an autopsy observation of the fulminant course of hepatitis of unclear etiology with HPgV persistence. Given the difficulties in establishing the etiology of cryptogenic hepatitis, initially, when analyzing this case, it was proposed to link the presence of HPgV with the development of fulminant hepatitis. Despite the detection of the virus in the blood and the hepatitis clinic, there are no causal relationships between these phenomena, as the article provides data from various researches. The wide spread of the virus in the human population and the absence of its etiological role in the development of pathological processes are shown.