Involvement of endoand exoantigens in the development of the autoimmune reaction-Reference-Cited by-同舟云学术

Involvement of endoand exoantigens in the development of the autoimmune reaction

Published:2023-01-18 Issue:8 Volume: Page:113-118
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Trubitsyna I. E.¹^ORCID,Dubtsova E. A.¹,Abdulatipova Z. M.¹,Moskaeva E. .²,Tarasova T. V.³,Smirnova A. V.⁴,Ruchkina I. N.¹,Vorobyova N. N.¹,Lesko K. A.¹,Malykh M. .¹,Vasilyeva I. S.⁵,Vasiliev V. V.⁵,Papysheva L. D.¹,Kleshcheva T. V.⁶,Kleshchev V. V.⁶,Efremov L. I.¹,Drozdova G. .²,Vinokurova L. V.¹

Affiliation:

1. Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow

2. Peoples’ Friendship University of Russia

3. Mordovian State University Ogareva

4. Moscow Clinical Research Center named after A. S. Loginova Department of Health of Moscow; Federal State Budgetary Institution “National Medical Research Cancer Center named after N. N. Blokhin” of the Ministry of Health of Russia

5. State Budgetary Health Institution of the Moscow Region “Moscow Regional Research Clinical Institute named after V.I. M. F. Vladimirsky”

6. Financial University under the Government of the Russian Federation

Abstract

The immune inflammatory reaction is involved in the formation of structural damage in organs with low immune resistance, but the causal stages of the formation of this reaction are poorly understood. Clinicians are faced with the fact that in patients with acute and chronic pancreatitis of alcoholic etiology, a reactive inflammatory reaction is observed in the mucous membrane (MM) of the stomach and / or duodenum. This effect was the reason that experimental studies were carried out on 45 white Wistar rats weighing 180-220 g. and duodenum (DOD). For this, a classical immunization scheme was used. Rats were taken out of the experiment on days 5, 10, and 17; after autopsy, morphological studies of the pancreas, gastric mucosa, and SOD were performed. Undoubtedly, the emerging immune response of the macroorganism to damage contributes to the development of an autoimmune reaction, in response to destruction and an inflammatory reaction, as a result, structural and functional damage to its own tissues occurs. The involvement of several organs in the inflammatory reaction depends on the local immune tolerance of the organ to endoantigens. A decrease in tolerance leads to a combined pathology, the impetus for which is damage to the “primary” organ, which is not always possible to identify. At the same time, antibodies to endoantigens are formed from damaged cellular structures.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

Reference7 articles.

1. Trubitsyna I.E., Ruchkina I. N., Mikhailova S. F., et al. MALT - the system of the mucous membrane of the gastrointestinal tract. Experimental and clinical gastroenterology. 2018;159(11):83-87. (In Russ.)@@ Trubitsyna I. E., Ruchkina I. N., Mikhailova S. F., i soavt. MALT - sistema slizistoi obolochki zheludochno-kishechnogo trakta //Eksperimental'naya i klinicheskaya gastroenterologiya. 2018. № 11 (159). S. 83-87. Experimental and Clinical Gastroenterology. 2018; № 11. - S. 83-86. (In Russ.)

2. Ado A.D., Ishimova L. M. Pathological physiology. Moscow; Triad-X, 2000, 607 P. (in Russ.) Special Edition Year: 2000 ISBN: 5-8249-0023-X.@@ Ado A. D., Ishimova L. M. Patologicheskaya fiziologiya. Uchebnik. Moskva; Triada-Kh, 2000-607 s. SpetsLit God izdaniya: 2000 ISBN: 5-8249-0023-Kh.

3. Khaitov R.M., Ignatieva G. A., Sidorovich I. G. Immunology. Norm and pathology. - 3rd ed., Moscow, Medicine, 2010, 752 P. (in Russ.)@@ Khaitov R. M., Ignat'eva G. A., Sidorovich I. G. Immunologiya. Norma i patologiya. Uchebnik. - 3-e izd., Moskva., Meditsina, 2010. - 752 s.

4. Chereshnev V. Clinical Pathophysiology. St. Petersburg. SpetsLit, 2012. (in Russ.) 830 P. ISBN: 978-5-299-00511-0.@@ Chereshnev V. Klinicheskaya patofiziologiya. SPb: SpetsLit, 2012-830 s. ISBN: 978-5-299-00511-0.

5. Chereshnev V.A., Shereshneva M. V. Immunological mechanisms of local inflammation. Medical Immunology. 2011;13(6):557-568. (in Russ.)@@ Chereshnev V.A, Shereshneva M. V. Immunologicheskie mekhanizmy lokal'nogo vospaleniya //Meditsinskaya immunologiya 2011, t. 13 № 6 s. 557-568.