The role of infectious agents and the gut microbiome in the development of the autistic spectrum in children

Author:

Zatevalov A. M.1ORCID,Garbuzov A. A.1ORCID,Ruzhentsova T. A.2ORCID,Bayrakova A. L.1ORCID,Orlova V. A.3ORCID,Mikhailova I. I.3ORCID,Meshkova N. A.4ORCID

Affiliation:

1. Gabrichevsky Research Institute for Epidemiology and Microbiology

2. Gabrichevsky Research Institute for Epidemiology and Microbiology; Moscow Medical University “Reaviz”

3. I. Mechnikov Research Institute of Vaccines and Sera

4. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)

Abstract

The article presents the results of studies of microbiome features in patients with autism spectrum disorders. The role of the microbiota as a part of the enteral nervous system influencing the dynamics of autism symptoms is considered. The links between eating behavior and the severity of autistic disorders, increased permeability of the gastrointestinal mucosa and hypoxia of brain cells, the nature of intestinal dysbiotic disorders, the severity and clinical manifestations of autism are shown. Taking into account the presented data, optimal approaches to the diagnosis and therapy of autism spectrum disorders are shown, which can significantly improve the quality of life of patients.

Publisher

LLC Global Media Technology

Reference52 articles.

1. The International Classification of Diseases ICD-10 is a short version based on the International Statistical Classification of Diseases and Health-Related Problems, 10th revision, adopted by the 43rd World Health Assembly. Adapted version in three parts. 593 p. (In Russ.) Available at: https://www.cito-priorov.ru/cito/files/telemed/Perechen_kodov_MKB.pdf. Accessed: 09.11.2023.@@ Mezhdunarodnaya klassifikatsiya boleznei MKB-10 Kratkii variant, osnovannyi na Mezhdunarodnoi statisticheskoi klassifikatsii boleznei i problem, svyazannykh so zdorov'em, 10-go peresmotra, prinyatoi 43-ei Vsemirnoi Assambleei Zdravookhraneniya. Adaptirovannyi variant v trekh chastyakh. 593 s. URL https://www.cito-priorov.ru/cito/files/telemed/Perechen_kodov_MKB.pdf. Data obrashcheniya: 09.11.2023.

2. Tiganov A.S. A Guide to Psychiatry. Ch. 1, 2. M: Medicine, 1999. 712 pp. (In Russ.). Available at: https://files.student-it.ru/previewfile/11055. Accessed: 09.11.2023.@@ Tiganov A. S. Rukovodstvo po psikhiatrii v 2 tomakh. M.: Meditsina. 1999. 712 s. URL: https://files.student-it.ru/previewfile/11055. Data obrashcheniya: 09.11.2023.

3. Arberas C., Ruggieri V. Autismo. Aspectos genéticos y biológicos [Autism. Genetic and biological aspects]. Medicina (B Aires). 2019;79(Suppl 1):16-21. Spanish. PMID: 30776274.

4. Bhandari R., Paliwal J. K., Kuhad A. Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors. Adv Neurobiol. 2020;24:97-141. doi: 10.1007/978-3-030-30402-7_4.

5. Sealey L.A., Hughes B. W., Sriskanda A. N., Guest J. R., Gibson A. D., Johnson-Williams L., Pace D. G., Bagasra O. Environmental factors in the development of autism spectrum disorders. Environ Int. 2016 Mar;88:288-298. doi: 10.1016/j.envint.2015.12.021.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3