Insulin therapy in acute coronary syndromes: an appraisal of completed and ongoing randomised trials with important clinical end points-Reference-Cited by-同舟云学术

Insulin therapy in acute coronary syndromes: an appraisal of completed and ongoing randomised trials with important clinical end points

Published:2008-01-01 Issue:4 Volume:5 Page:276-284
ISSN:1479-1641
Container-title:Diabetes and Vascular Disease Research
language:en
Short-container-title:Diabetes and Vascular Disease Research

Author:

Goyal Abhinav¹,Nerenberg Kara²,Gerstein Hertzel C²,Umpierrez Guillermo¹,Wilson Peter WF¹

Affiliation:

1. Department of Medicine, Emory School of Medicine, Atlanta, GA, US.

2. Department of Medicine and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

Abstract

Insulin therapy was first proposed as an adjunctive therapy in patients with acute coronary syndromes (ACS) in the 1960s. Since then, numerous randomised clinical trials have been conducted to determine the efficacy and to define the role of insulin therapy in ACS. This review will discuss: 1) completed trials of insulin therapy in ACS, including both glucose-insulin-potassium (GIK) approaches and non-GIK approaches; 2) trials of insulin therapy in critically ill non-ACS patients and the lessons from these trials that can be applied to trials of insulin in ACS patients; and 3) a summary of ongoing and planned trials of insulin in ACS patients.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://journals.sagepub.com/doi/pdf/10.3132/dvdr.2008.040

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