Affiliation:
1. Rostov State Medical University
Abstract
Objective: to develop a model for predicting the severe course of bronchial asthma (BA) in children.
Materials and methods: a comprehensive examination was conducted of 213 children aged 3 to 12 years suffering from atopic asthma (mild course was observed in 85.0%, moderate — in 10.3%, severe — 4.7%). A statistical analysis of clinical and laboratory parameters was performed using the logistic regression method, which allowed us to identify a number of factors that increase the probability of developing a more severe course of BA in children.
Results. A mathematical model for predicting the risk of severe bronchial asthma in children has been developed, including such factors as the child's age, the degree of respiratory failure, the value of the peak expiratory rate, the duration of the disease, and the presence of an association of exacerbations of the disease with changes in the weather and physical activity. A computer program has also been developed that allows you to automatically calculate the amount of risk after entering the child's data.
Conclusion. The use of this model makes it possible to predict the further course of BA with a high degree of confidence, and, consequently, to correct the basic therapy in time to prevent the development of complications in a sick child.
Publisher
Association of Pediatric Allergologists and Immunologists of Russia
Reference11 articles.
1. Aw M, Penn J, Gauvreau GM, Lima H, Sehmi R. Atopic March: Collegium Internationale Allergologicum Update 2020. Int. Arch. Allergy Immunol. 2020; 181 (1): 1–10. https://doi.org/10.1159/000502958.
2. Odhiambo JA, Williams HC, Clayton TO et al. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol. 2009; 124 (6): 1251–1258: e23. https://doi.org/10.1016/j.jaci.2009.10.009.
3. Williams H, Stewart A, Mutius E von, Cookson W, Anderson HR. International Study of Asthma and Allergies in Childhood (ISAAC). Phase One and Three Study Groups. Is eczema really on the increase worldwide? J Allergy Clin Immunol. 2008; 121 (4): 947–954: e15. https://doi.org/10.1016/j.jaci.2007.11.0044.
4. Национальная программа «Бронхиальная астма у детей. Стратегия лечения и профилактика». 5-е изд., перераб. и доп. М.: Оригинал-макет. 2017: 160. [Nacional’naya programma «Bronhial’naya astma u detej. Strategiya lecheniya i profilaktika». 5-e izd., pererab. i dop. M.: Original-maket. 2017: 160. (In Russ.)]
5. 2020 GINA Report, Global Strategy for Asthma Management and Prevention. GINA, 2020: 211. URL: https://ginasthma.org/gina-reports/ (23.06.2020).