Roxadustat Improves Erythropoietin Antibody-Mediated Pure Red Cell Aplasia in a Patient with Hemodialysis-Reference-Cited by-同舟云学术

Roxadustat Improves Erythropoietin Antibody-Mediated Pure Red Cell Aplasia in a Patient with Hemodialysis

Published:2021-09-09 Issue:2 Volume:51 Page:189-192
ISSN:0253-5068
Container-title:Blood Purification
language:en
Short-container-title:Blood Purif

Author:

Li Sijia,Chen Xueqin,Hu Penghua,Wu Suijing,Ma Jianchao,Li Zhuo,Wu Xiuchuan,Wen Feng,Fu Xia,Feng Zhonglin,Tao Yiming,Li Bohou,Fu Lei,Huang Renwei,He Chaosheng,Shi Wei,Liang Xinling^ORCID,Liu Shuangxin^ORCID

Abstract

Anemia is a common complication of chronic kidney disease (CKD). Recombinant human erythropoietin (rHu-EPO) is used extensively in patients with CKD. However, anti-erythropoietin (anti-EPO) antibody has been reported during rHu-EPO treatment, which causes pure red cell aplasia (PRCA). We presented a case of 75-year-old man, who underwent hemodialysis for 2 years. He developed PRCA during rHu-EPO treatment. The rHu-EPO was immediately discontinued, and the patient was given roxadustat treatment. After 6 months of roxadustat treatment, the anti-EPO antibody was disappeared, and hemoglobin recovered normal range. The results suggest that roxadustat can be used to treat patients with anti-EPO antibody-mediated PRCA without immunosuppressive therapy.

Publisher

S. Karger AG

Subject

Nephrology,Hematology,General Medicine

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