Clinical Course of Migraine during Strict Quarantine due to SARS-CoV-2: Effect of Psychiatric Comorbidities in a Clinical Cohort

Abstract

<b><i>Objective:</i></b> During the SARS-CoV-2 pandemic, there has been a significant increase in the prevalence of anxiety and depression. This study sought to establish the probability of migraine progression by comparing data from week 0 with week 12 of quarantine. <b><i>Methods:</i></b> A retrospective cohort study. Three hundred ten patients were included, 238 with episodic migraine and 33 with chronic migraine; they all completed a self-administered questionnaire with demographic, clinical, and psychiatric symptom information. A multivariate statistical analysis was conducted to identify factors associated with the progression of migraine. <b><i>Results:</i></b> This study demonstrated a 22.5% progression probability from episodic migraine to chronic migraine with an RR 2.7 and CI (1.92–3.95, <i>p</i> &#x3c; 0.001). The increase in depression scores (<i>p</i> &#x3c; 0.005), anxiety (<i>p</i> &#x3c; 0.001), and alteration in sleep quality (<i>p</i> &#x3c; 0.003) were associated with the worsening of migraine. <b><i>Conclusion:</i></b> During the SARS-CoV-2 pandemic, depression, anxiety, and the deterioration of sleep quality influenced the probability of progression from episodic migraine to chronic migraine.