Hypertension Resolution after Laparoscopic Adrenal Tumor Resection in Patients of Adrenal Incidentaloma with Normal Hormone Levels

Abstract

<b><i>Introduction:</i></b> Postoperative hypertension resolution among patients with adrenal incidentalomas and normal hormone levels was unknown. Identifying the predictive factors was beneficial to the management of adrenal incidentalomas. <b><i>Methods:</i></b> We conducted a retrospective cohort study, recruiting patients undergoing laparoscopic adrenal tumor resection for adrenal incidentaloma with hypertension and normal hormone levels. Demographic, clinical, treatment, and laboratory data were collected and compared. We used univariable and multivariable logistic regression methods to identify the predictive factors of postoperative hypertension resolution. <b><i>Results:</i></b> Of the 171 patients in our study, 130 (76.0%) patients performed a resolution of hypertension, and 57 (33.3%) patients had a significant reduction. Multivariate logistic regression analysis showed that the male sex (odds ratio (OR) 0.305, 95% confidence interval (CI): 0.098–0.948, <i>p</i> = 0.040), body mass index (BMI) (OR 0.973, 95% CI: 0.670–0.938, <i>p</i> = 0.007), aldosterone and plasma renin activity ratio (APR) in erect position (OR 1.206, 95% CI: 1.042–1.397, <i>p</i> = 0.012), and preoperative systolic pressure (OR 1.044, 95% CI: 1.009–1.080, <i>p</i> = 0.014), were significantly associated with the outcomes of hypertension resolution. <b><i>Discussion/Conclusion:</i></b> Adrenal incidentalomas patients with hypertension and normal hormone levels would perform hypertension resolution after laparoscopic adrenal tumor resection, especially for females with low BMI, high preoperative systolic blood pressure, and high APR (erect position).