Assessment of Drug Interactions with Online Electronic Checkers in Multi-Pathological Patients

Abstract

<b><i>Introduction:</i></b> Multi-pathological patients are at high risk of drug interactions and side effects. We aimed to assess the usefulness of 3 online drug interaction checkers. <b><i>Methods:</i></b> In a cross-sectional study, carried out in the Medicine Department of Hospital General of Castellon, Spain, in February 2020, we assessed drug interaction detection with 3 online electronic checkers, Drugs.com, Lexicomp®, and Medscape, and compared results obtained with the 3 tools. From every hospitalized patient, we obtained the list of drugs he or she had been taking until admission. Bivariable tests were used for analysis. <i>p</i> values &#x3c;0.05 were considered significant. <b><i>Results:</i></b> We included data from 134 patients; 68 (51%) were male; median (and interquartile range) of their age was 82 (76–88) years. A total of 1,082 substance drugs were entered in the checkers. The number of highest grade interactions found with every program was Drugs.com 85, Lexicomp® 33, and Medscape 67. Positive correlations were found between age and number of drug substances prescribed (<i>p</i> = 0.009) and between number of drug substances prescribed and interactions found with any of the 3 checkers (<i>p</i> &#x3c; 0.001 in all 3 cases). Regarding highest grade interactions, agreement among all 3 checkers was poor. <b><i>Conclusions:</i></b> The 3 online checkers we assessed found a large number of interactions. The 3 programs gave very discrepant results. <b><i>Impact on Practice Statements:</i></b> The analyzed programs, Drugs.com, Lexicomp®, and Medscape Interactions, found a large number of drug interactions in the studied patients. The 3 programs gave very discrepant results among them.