Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects

Abstract

<b><i>Background:</i></b> Cr is secreted by the proximal tubules and thus Cr clearance (<i>C</i>_cr) can overestimate inulin clearance (<i>C</i>_in). However, in some cases, <i>C</i>_cr can even underestimate <i>C</i>_in. This suggests that Cr could be reabsorbed in the tubuli. We examined the clinical parameters that are associated with tubular Cr reabsorption. <b><i>Methods:</i></b> In 80 kidney donor candidates (53.9 ± 13.2 years, 29 males), <i>C</i>_in and para-aminohippuric acid clearance were measured simultaneously. Intrarenal hemodynamic parameters were calculated by Gomez’s formulae. To quantify the secretory component of <i>C</i>_cr (SF_cr), it was calculated as follows: SF_cr = (<i>C</i>_cr − <i>C</i>_in)/<i>C</i>_cr. <b><i>Results:</i></b> Twenty-five subjects (31.3%) showed SF_cr values &#x3c;0. SF_cr that correlated significantly and negatively with efferent arteriolar resistance (<i>R</i>_e) and glomerular hydrostatic pressure (<i>P</i>_glo) (<i>R</i>_e: <i>r</i> = −0.30, <i>p</i> = 0.008; <i>P</i>_glo: <i>r</i> = −0.28, <i>p</i> = 0.025). In multiple regression analyses, <i>R</i>_e and <i>P</i>_glo were significantly and negatively associated with SF_cr after adjustment for other confounders. <b><i>Conclusions:</i></b> These findings suggest that tubular reabsorption of Cr can occur in some cases. Intrarenal glomerular hemodynamic burden may be related to tubular creatinine reabsorption, which possibly leads to lower <i>C</i>_cr values.