Bilateral Vestibular Schwannomas in a Patient with Ring Chromosome 22: Case Report and Review of the Literature-Reference-Cited by-同舟云学术

Bilateral Vestibular Schwannomas in a Patient with Ring Chromosome 22: Case Report and Review of the Literature

Published:2021-02-05 Issue: Volume: Page:1-5
ISSN:1016-2291
Container-title:Pediatric Neurosurgery
language:en
Short-container-title:Pediatr Neurosurg

Author:

Nussbaum Penelope E.,Patel Puja D.,Nussbaum Leslie A.,Hilton Christopher W.,Nussbaum Eric S.

Abstract

Introduction: Ring chromosome 22 (r[22]) can lead to the development of intracranial tumors such as meningiomas, neurofibromas, and schwannomas similar to neurofibromatosis 2 (NF2). Case Presentation: An 18-year-old female with r(22) and a history of global development delay and cognitive impairment presented with sudden hearing loss. MRI revealed bilateral vestibular schwannomas. Given documented audiologic decline in the patient’s hearing, the larger tumor was treated with CyberKnife fractionated stereotactic radiosurgery, and the smaller tumor is being monitored. Conclusion: This case provides further evidence that patients with r(22) can develop clinical features of NF2, including the development of bilateral vestibular schwannomas, and should be monitored for hearing disturbances starting in puberty as a warning sign for these tumors.

Publisher

S. Karger AG

Subject

Clinical Neurology,General Medicine,Surgery,Pediatrics, Perinatology, and Child Health

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