Life-Threatening Hyperkalemia following Low-Dose Trimethoprim-Sulfamethoxazole: A Case Report

Author:

Katagiri HikaruORCID,Sato NobuhiroORCID,Inoue Yukinori,Muto Koji,Tanaka Hiroko,Hirose Yasuo

Abstract

Hyperkalemia is a known adverse effect of trimethoprim-sulfamethoxazole, usually occurring at high doses. However, fatal hyperkalemia at low doses has rarely been reported. We present the case of an 80-year-old Japanese woman who experienced a cardiac arrest due to severe hyperkalemia after starting low-dose trimethoprim-sulfamethoxazole. This case suggests that trimethoprim-sulfamethoxazole can cause severe hyperkalemia and sudden death, even at low doses. When trimethoprim-sulfamethoxazole is administered, even at low doses, periodic monitoring of electrolyte levels is necessary, with the interval depending on concomitant medications and renal function.

Publisher

S. Karger AG

Subject

Materials Science (miscellaneous)

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1. Cotrimoxazole/spironolactone;Reactions Weekly;2024-08-03

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