Psoriasis Exacerbation after Candida Antigen Immunotherapy Injection

Author:

Sarsik Sameh MagdyORCID,Soliman Sarah Hamdy

Abstract

<b><i>Background:</i></b> Immunotherapy as wart treatment has been proposed as a successful and well-tolerated treatment option. However, as their action is not confined to the site of injection, the activation of the immune system in a way may alter the immune state of the patient. <b><i>Case Presentation:</i></b> A case of 29-year-old patient who experienced psoriasis exacerbation and psoriatic arthritis within days following <i>Candida</i> antigen immunotherapy injection for resistant filiform wart management. <b><i>Conclusion:</i></b> <i>Candida</i> antigen injection may cause psoriasis exacerbation, as TNFα and subsequent T-helper 1 induction is crossroad in both psoriasis and <i>Candida</i> antigen immunotherapy. Therefore, we report this case to state that besides the effectiveness of <i>Candida</i> antigen for wart therapy, caution should be considered if used in patients who are susceptible to psoriasis with meticulous follow-up or better to apply an alternative treatment option.

Publisher

S. Karger AG

Subject

Dermatology

Reference10 articles.

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3. Nofal A, Salah E, Nofal E, Yosef A. Intralesional antigen immunotherapy for the treatment of warts: current concepts and future prospects. Am J Clin Dermatol. 2013 Aug;14(4):253–60.

4. Horn TD, Johnson SM, Helm RM, Roberson PK. Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trial. Arch Dermatol. 2005 May;141(5):589–94.

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1. Candida-antigen;Reactions Weekly;2021-08

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