Psoriasis Exacerbation after Candida Antigen Immunotherapy Injection

Abstract

<b><i>Background:</i></b> Immunotherapy as wart treatment has been proposed as a successful and well-tolerated treatment option. However, as their action is not confined to the site of injection, the activation of the immune system in a way may alter the immune state of the patient. <b><i>Case Presentation:</i></b> A case of 29-year-old patient who experienced psoriasis exacerbation and psoriatic arthritis within days following <i>Candida</i> antigen immunotherapy injection for resistant filiform wart management. <b><i>Conclusion:</i></b> <i>Candida</i> antigen injection may cause psoriasis exacerbation, as TNFα and subsequent T-helper 1 induction is crossroad in both psoriasis and <i>Candida</i> antigen immunotherapy. Therefore, we report this case to state that besides the effectiveness of <i>Candida</i> antigen for wart therapy, caution should be considered if used in patients who are susceptible to psoriasis with meticulous follow-up or better to apply an alternative treatment option.