Real-World Characteristics of Patients with Severe Asthma prior to Starting Dupilumab: The ProVENT Study
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Published:2023-12-12
Issue:1
Volume:103
Page:10-21
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ISSN:0025-7931
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Container-title:Respiration
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language:en
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Short-container-title:Respiration
Author:
Korn Stephanie,Schmidt Olaf,Timmermann Hartmut,Watz Henrik,Gappa Monika,Radwan Amr,De Prado Gómez Lucia,Atenhan Anne,Barbus Sebastian,Thakur Mayank,Lommatzsch Marek
Abstract
<b><i>Introduction:</i></b> Dupilumab is approved for the treatment of severe type 2 (T2) asthma; however, the characteristics of patients receiving dupilumab in routine clinical practice are incompletely understood. This study describes the characteristics of patients with severe asthma before dupilumab treatment in a real-world setting. <b><i>Methods:</i></b> This interim analysis of an ongoing real-life study of dupilumab assessed baseline characteristics of the first patient cohort enrolled in the ProVENT study. <b><i>Results:</i></b> A total of 99 patients (59% females) were analyzed (17% received another biologic before dupilumab treatment and 15% were on maintenance oral corticosteroid treatment). Adult-onset asthma (>18 years) and an allergic phenotype were documented in 58% and 48% of patients, respectively. Median (interquartile range) age was 54 (40–61) years; the median number of exacerbations in the last 24 months was 1 (0–3); median fractional exhaled nitric oxide (FeNO) value was 38 (23–64) ppb; and median blood eosinophils (bEOS) count was 184 (8–505) cells/µL. According to the United Kingdom Severe Asthma Registry classification, 53% of patients had T2 intermediate asthma (bEOS ≥150 cells/µL or FeNO ≥25 ppb), 17% had T2 high asthma (bEOS ≥150 cells/µL and FeNO ≥25 ppb), and 4% had T2 low asthma (bEOS <150 cells/µL and FeNO <25 ppb). At least one GINA criterion for T2 airway inflammation was documented in 70% of patients. T2 comorbidities were observed in 64% of patients. <b><i>Conclusions:</i></b> This analysis suggests that patients eligible for dupilumab treatment display various clinical and biochemical characteristics rather than one clear-cut phenotype.
Subject
Pulmonary and Respiratory Medicine