Comparison of Stereotactic Radiosurgery and Radiofrequency Ablation for Trigeminal Neuralgia in Multiple Sclerosis Patients

Abstract

<b><i>Background:</i></b> The optimal treatment for medically refractory trigeminal neuralgia in multiple sclerosis (MS-TN) patients is unknown. <b><i>Objective:</i></b> To compare treatment outcomes between stereotactic radiosurgery (SRS) and radiofrequency ablation (RFA). <b><i>Methods:</i></b> We performed a retrospective study of MS-TN patients treated with SRS or RFA between 2002 and 2019. Outcomes included degree of pain relief, pain recurrence, and sensory changes, segregated based on initial treatment, final treatment following retreatment with the same modality, and crossover patients. <b><i>Results:</i></b> Sixty surgical cases for 42 MS-TN patients were reviewed. Initial pain freedom outcomes and rates of retreatment were similar (SRS: 30%; RFA: 42%). RFA resulted in faster onset of pain freedom (RFA: &#x3c;1 week; SRS: 15 weeks; <i>p</i> &#x3c; 0.001). SRS patients with pain relief had longer intervals to pain recurrence at 2 years (<i>p</i> = 0.044). Final treatment outcomes favored RFA for pain freedom/off-medication outcomes (RFA: 44%; SRS: 11%; <i>p</i> = 0.031), though RFA resulted in more paresthesia (RFA: 81%; SRS: 39%; <i>p</i> = 0.012). Both provided at least 80% of adequate pain relief. Crossover patients did not have improved pain relief. <b><i>Conclusions:</i></b> SRS and RFA are both valid surgical options for MS-TN. Discussion with providers will need to balance patient preference with their unique treatment characteristics.