Secondary Metabolites Governing Microbiome Interaction of Staphylococcal Pathogens and Commensals

Author:

Torres Salazar Benjamin O.,Heilbronner Simon,Peschel Andreas,Krismer BernhardORCID

Abstract

Various <i>Staphylococcus</i> species colonize skin and upper airways of warm-blooded animals. They compete successfully with many other microorganisms under the hostile and nutrient-poor conditions of these habitats using mechanisms that we are only beginning to appreciate. Small-molecule mediators, whose biosynthesis requires complex enzymatic cascades, so-called secondary metabolites, have emerged as crucial components of staphylococcal microbiome interactions. Such mediators belong to a large variety of compound classes and several of them have attractive properties for future drug development. They include, for instance, bacteriocins such as lanthipeptides, thiopeptides, and fibupeptides that inhibit bacterial competitor species; signaling molecules such as thiolactone peptides that induce or inhibit sensory cascades in other bacteria; or metallophores such as staphyloferrins and staphylopine that scavenge scant transition metal ions. For some secondary metabolites such as the aureusimines, the exact function remains to be elucidated. How secondary metabolites shape the fitness of <i>Staphylococcus</i> species in the complex context of other microbial and host defense factors remains a challenging field of future research. A detailed understanding will help to harness staphylococcal secondary metabolites for excluding the pathogenic species <i>Staphylococcus aureus</i> from the nasal microbiomes of at-risk patients, and it will be instrumental for the development of advanced anti-infective interventions.

Publisher

S. Karger AG

Subject

Cell Biology,Religious studies,Applied Microbiology and Biotechnology,Physiology,Biochemistry,Microbiology,Biotechnology

Reference146 articles.

1. Angelopoulou A, Warda AK, O'Connor PM, Stockdale SR, Shkoporov AN, Field D, et al. Diverse Bacteriocins Produced by Strains From the Human Milk Microbiota. Front Microbiol. 2020 May 19;11(788):788.

2. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan;30(1):108–60.

3. Asaduzzaman SM, Nagao J, Iida H, Zendo T, Nakayama J, Sonomoto K. Nukacin ISK-1, a bacteriostatic lantibiotic. Antimicrob Agents Chemother. 2009 Aug;53(8):3595–8.

4. Aso Y, Sashihara T, Nagao J, Kanemasa Y, Koga H, Hashimoto T, et al. Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1. Biosci Biotechnol Biochem. 2004 Aug;68(8):1663–71.

5. Bagley MC, Dale JW, Merritt EA, Xiong X. Thiopeptide Antibiotics. Chem Rev. 2005;105(2):685–714.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3