Routine Cancer Treatment Regimens and Its Impact on Fine Motor Dexterity in Breast Cancer

Abstract

<b><i>Introduction:</i></b> Breast cancer can be a major challenge for those affected. Knowledge of changes in fine motor dexterity in affected women due to routine cancer therapies can help guide effective support. <b><i>Methods:</i></b> For this prospective observational study, we collected data of 79 women with a mean age 54.6 ± 9.5 years prior to, after breast cancer therapy (T1), and at 3-month follow-up. The fine motor dexterity was assessed for 4 treatment subgroups: SC = Surgery + Chemotherapy, SCR = Surgery + Chemotherapy + Radiotherapy Therapy, SR = Surgery + Radiotherapy, and S = Surgery. <b><i>Results:</i></b> Over time, women with breast cancer showed significant decreases in fine motor dexterity across all treatment groups (<i>p</i> &#x3c; 0.001). The strongest negative effect was seen in the treatment groups receiving additional chemotherapy. SCR group showed pronounced limitations for dominant hand (DH) −12%; non-dominant hand (NDH) −15%; both hands (BH) −17%; assembly (ASSY) −11% at T1. Significant interaction was noticeable in DH (<i>F</i> = 5.59, <i>p</i> &#x3c; 0.001), NDH (<i>F</i> = 6.61, <i>p</i> &#x3c; 0.001), BH (<i>F</i> = 13.11 <i>p</i> &#x3c; 0.001), and ASSY (<i>F</i> = 5.84 <i>p</i> &#x3c; 0.001). <b><i>Discussion/Conclusion:</i></b> Our study showed that the extent of change in fine motor dexterity depends on the treatment regimen. The detection of unmet care needs could help to personalize and optimize clinical and survivorship care. Based on our findings, multidisciplinary support initiated early in breast cancer therapy is required.