The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition-Reference-Cited by-同舟云学术

The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition

Published:2020-12-14 Issue: Volume: Page:1-23
ISSN:1422-6405
Container-title:Cells Tissues Organs
language:en
Short-container-title:Cells Tissues Organs

Author:

Adiga Divya,Radhakrishnan Raghu,Chakrabarty Sanjiban,Kumar Prashant,Kabekkodu Shama Prasada

Abstract

Despite substantial advances in the field of cancer therapeutics, metastasis is a significant challenge for a favorable clinical outcome. Epithelial to mesenchymal transition (EMT) is a process of acquiring increased motility, invasiveness, and therapeutic resistance by cancer cells for their sustained growth and survival. A plethora of intrinsic mechanisms and extrinsic microenvironmental factors drive the process of cancer metastasis. Calcium (Ca2+) signaling plays a critical role in dictating the adaptive metastatic cell behavior comprising of cell migration, invasion, angiogenesis, and intravasation. By modulating EMT, Ca2+ signaling can regulate the complexity and dynamics of events leading to metastasis. This review summarizes the role of Ca2+ signal remodeling in the regulation of EMT and metastasis in cancer.

Publisher

S. Karger AG

Subject

Histology,Anatomy

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