MRI Evaluation of Global Developmental Delay: A Retrospective Study

Abstract

Introduction: Global developmental delay (GDD) is defined as a significant delay in one or more developmental domains. Aims and Objectives: To study the prevalence of normal and abnormal magnetic resonance imaging (MRI) in pediatric patients presenting with GDD, and how abnormal MRI helps in the diagnosis of children with GDD. Materials and Methods: This was a retrospective observational study conducted at the King Fahad Specialist Hospital Dammam. MRI of the brain was conducted on 170 patients who were referred by the Pediatric Neurology Department between February 2016 and April 2018. Results: Normal MRI findings were seen in 45.3% and 54.7% had abnormal findings. The ventricles and white matter, mainly the corpus callosum, were the most commonly affected anatomical structures. In 15 (16%) patients, MRI enabled a direct diagnosis, and in 22 (23.6%) MRI suggested a diagnosis which was confirmed by further investigation. Conclusion: The clinical diagnosis of GDD should not be the end point, but rather a springboard for an effective search for causal factors. MRI is the best investigation with a high yield in such patients.