Being Elderly Is Associated with Infectious and Fatal Postoperative Complications in Ulcerative Colitis Patients

Abstract

<b><i>Introduction:</i></b> It is well known that the infectious complications and mortality rates are increased among elderly individuals with ulcerative colitis (UC) during medical treatment. However, there have been few reports on surgery in elderly individuals with UC, and some cohort studies have reported surgical complication and mortality rates similar to those in nonelderly individuals. <b><i>Methods:</i></b> UC patients who underwent colectomy at the Hyogo College of Medicine between April 2012 and March 2020 were included in this study. The patients were classified as elderly (≥65) or nonelderly (&#x3c;65). Characteristics and postoperative complications were analyzed and compared between the groups; possible risk factors for infectious and fatal complications were also analyzed. <b><i>Results:</i></b> In all, 136/599 (22.7%) elderly patients were included. The incidence of infectious and fatal complications was 177/599 (29.5%) and 18/599 (3%), respectively. These complication rates were significantly higher in the elderly than the nonelderly group (<i>p</i> &#x3c; 0.01). Age ≥65 years at surgery (OR = 2.92, 95% CI: 1.87–4.57, <i>p</i> &#x3c; 0.01) was identified as an independent risk factor for infectious complications. Age ≥65 years at surgery (OR = 8.03, 95% CI: 2.16–29.83, <i>p</i> &#x3c; 0.01), American Society of Anesthesiologists score ≥3 (OR = 6.00, 95% CI: 1.40–25.6 p = 0.02), and urgent/emergent surgery (OR = 16.24, 95% CI: 1.70–154.95, <i>p</i> = 0.02) were identified as independent risk factors for fatal complications. <b><i>Discussion/Conclusion:</i></b> Age ≥65 years was identified as a risk factor for infectious and fatal complications. It is important to avoid urgent/emergent surgery in elderly patients with an ASA score &#x3e;3 by emphasizing surgical and medical collaboration and optimizing the timing of surgery.