Author:
Li Meiqiong,Long Jiaye,Yang Miyang,Pang Yingrong,Chen Baoxiang,Li Hong
Abstract
<b><i>Introduction:</i></b> The link between cruciferous vegetables (CVs) and ovarian cancer (OC) is still uncertain. This meta-analysis is intended to investigate the association between CV consumption and the risk of OC, as well as to conduct a dose-response analysis to determine the degree of correlation between them. <b><i>Methods:</i></b> We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases between database creation and October 2023. The present meta-analysis has been duly registered and assigned the registration number CRD42023470299. This study followed the PRISMA guidelines. The statistical analysis was performed using Stata 14.0 software. <b><i>Results:</i></b> There were a total of 7 cohort studies and 7 case-control studies with 7,269 cases and 742,952 subjects. The combined relative risk (RR) of the highest intake of CVs was 0.90 (95% confidence intervals [CIs]: 0.84–0.96; <i>I</i><sup>2</sup> = 54.7%; <i>p</i> = 0.007) compared to the lowest intake of CVs. The odds ratio (OR) was 0.97 (95% CIs: 0.86–1.08; <i>p</i> = 0.192) for cohort studies, and the RR was 0.79 (95% CIs: 0.67–0.91; <i>p</i> = 0.167) for case-control studies. The intake of CVs and the risk of OC were linearly correlated. Adding 15 g of CVs to the diet each day decreased the likelihood of developing OC by almost 4% (RR = 0.963, 95% CIs: 0.905–1.025; <i>p</i> = 0.235). <b><i>Conclusions:</i></b> Consumption of CVs may be linked to a lower risk of OC.