Abstract
<b><i>Introduction:</i></b> Metabolic or inflammatory markers may predict adverse outcomes in women with obesity. We sought to describe metabolic-obesity phenotypes of women using novel staging tools and investigate relationships with inflammation. <b><i>Methods:</i></b> In a cross-sectional study, we collected fasting blood samples from sixty-four females with body mass index (BMI) ≥28 kg/m<sup>2</sup>. Participants were classified as metabolically healthy or metabolically unhealthy obesity (MUO) using the cardiometabolic disease staging system (CMDS) and Edmonton obesity staging system (EOSS). Data were analyzed using independent sample <i>t</i> tests, Pearson’s correlations, and multiple logistic regression. <b><i>Results:</i></b> Mean (SD) age was 40.2 (9.3) years with median (IQR) BMI 31.8 (30.3–35.7) kg/m<sup>2</sup>. The prevalence of MUO was 46.9% and 81.3% using CMDS and EOSS criteria, respectively. Women with raised CMDS scores had higher C3 (1.34 [0.20] vs. 1.18 [0.15], <i>p</i> = 0.001) and C-reactive protein (CRP) (2.89 [1.31–7.61] vs. 1.39 [0.74–3.60], <i>p</i> = 0.034). C3 correlated with insulin (<i>r</i> = 0.52), hemoglobin A1c (<i>r</i> = 0.37), and C-peptide (<i>r</i> = 0.58), all <i>p</i> < 0.05. C3 above the median (>1.23 g/L) increased odds of raised CMDS score, when controlled for age, BMI, ethnicity, and smoking (OR = 6.56, 95% CI: 1.63, 26.47, <i>p</i> = 0.008). <b><i>Conclusion:</i></b> The prevalence of MUO was lower using CMDS than EOSS. C3 and CRP may be useful clinical biomarkers of risk or treatment targets in women with obesity.
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献