A Persistent Stress Response to Impeded Axonal Transport Leads to Accumulation of Amyloid-ß in the Endoplasmic Reticulum, and Is a Probable Cause of Sporadic Alzheimers Disease
Author:
Publisher
S. Karger AG
Subject
Neurology (clinical),Neurology
Reference18 articles.
1. Reimagining Alzheimer's Disease--An Age-Based Hypothesis
2. Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer’s disease?
3. Characterization of a CNS Cell Line, CAD, in which Morphological Differentiation Is Initiated by Serum Deprivation
4. The Cleavage Products of Amyloid- Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites
5. A phosphorylated, carboxy-terminal fragment of -amyloid precursor protein localizes to the splicing factor compartment
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1. Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications;Seminars in Cell & Developmental Biology;2020-03
2. A Role for Drosophila Amyloid Precursor Protein in Retrograde Trafficking of L1-Type Cell Adhesion Molecule Neuroglian;Frontiers in Cellular Neuroscience;2019-07-12
3. Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer’s Disease and Reconstruction of Relevant Biological Mechanisms;Scientific Reports;2018-07-24
4. Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane;Neurobiology of Disease;2018-06
5. Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease;Frontiers in Molecular Neuroscience;2017-09-15
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