Non-Invasive versus Invasive Assessment of Portal Hypertension in Chronic Liver Disease

Abstract

<b><i>Background:</i></b> Cirrhosis is one of the major causes of morbidity and mortality worldwide and the second leading cause of digestive disease mortality. Portal hypertension is the main driver of cirrhosis-related complications such as ascites and variceal bleeding. Portal hypertension is defined as a hepatic venous pressure gradient &gt;5 mm Hg, although it is clinically significant and associated with clinical complications when &gt;10 mm Hg. <b><i>Summary:</i></b> Therefore, detection of clinically significant portal hypertension (CSPH) in chronic advanced liver disease or compensated cirrhosis is of paramount importance to guide the management of these patients. <b><i>Key Messages:</i></b> This study aimed at revising the non-invasive and invasive tools for assessment of portal hypertension and risk stratification for CSPH in patients with chronic liver disease.