Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy-Reference-Cited by-同舟云学术

Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Published:2021-02-09 Issue:1 Volume:14 Page:17-23
ISSN:1662-6575
Container-title:Case Reports in Oncology
language:en
Short-container-title:Case Rep Oncol

Author:

Chamberlin Michael,Khan Sophia,Hernandez Cristal,Miettinen Markku,Wei Jun S.^ORCID,Khan Javed,Glod John,Rowe Lindsay,Kaushal Aradhana

Abstract

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.

Publisher

S. Karger AG

Subject

Oncology

Reference9 articles.

1. Das A, Das A, Bandyopadhyay D, Mishra V, Saha A. Aneurysmal benign fibrous histiocytoma presenting as a giant acrochordon on thigh. Indian Dermatol Online J. 2015;6(6):436–8.

2. Fletcher CD. The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology. 2006;48(1):3–12.

3. Doyle LA, Fletcher CD. Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2013;37(4):484–95.

4. Gleason BC, Fletcher CD. Deep “benign” fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 2008;32(3):354–62.

5. Guillou L, Gebhard S, Salmeron M, Coindre JM. Metastasizing fibrous histiocytoma of the skin: a clinicopathologic and immunohistochemical analysis of three cases. Mod Pathol. 2000;13(6):654–60.

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