Effects of Ischemic Reperfusion Injury and Remote Conditioning on Passive Leg Raising-Induced Brachial-Artery Dilation
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Published:2016
Issue:3
Volume:134
Page:320-324
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ISSN:0008-6312
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Container-title:Cardiology
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language:en
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Short-container-title:Cardiology
Author:
Bapat Manasi,Sharma Bhawna,Persits Andrew,Van Le Hue,Janani Jack,Kamran Haroon,Ramkissoon Keshwar,Salciccioli Louis,Lazar Jason M.
Abstract
Objectives: Passive leg raising (PLR) has been proposed to assess arterial vasodilator reserve and possibly endothelial function. Since endothelial function is sensitive to ischemic-reperfusion (I-R) injury, we determined the effects of I-R injury and ischemic conditioning on PLR-induced brachial-artery dilation (BAD), i.e. PLR-BAD. Methods: We induced PLR-BAD before and after ipsilateral arm I-R injury (7.5 min of occlusion) in 20 healthy males aged 29 ± 6 years. The protocol was repeated in combination with remote conditioning stimuli (3 × 30 s of contralateral arm occlusions). Results: PLR resulted in significant BAD (3.85%, p < 0.001) before but not after prolonged ischemia (0.25%, p = 0.38). I-R injury, along with either preischemic or postischemic conditioning restored the PLR-BAD response (before: 3.11%, p < 0.001 and after: 3.74%, p < 0.001). Conclusions: I-R injury blunts the BAD induced by PLR. Remote pre- and postconditioning restore this response. These findings are similar to those previously reported using hyperemia and ultrasound to assess BAD.
Subject
Pharmacology (medical),Cardiology and Cardiovascular Medicine