Author:
Marvin-Peek Jennifer,Shelton Valerie,Brassil Kelly,Fellman Bryan,Barr Austin,Chien Kelly Sharon,Hammond Danielle,Swaminathan Mahesh,Jain Nitin,Wierda William,Ferrajoli Alessandra,DiNardo Courtney
Abstract
<b><i>Introduction:</i></b> Promotion of self-efficacy can enhance engagement with health care and treatment adherence in patients with cancer. We report the outcomes of a pilot trial of a digital health coach intervention in patients with leukemia with the aim of improving self-efficacy. <b><i>Methods:</i></b> Adult patients with newly diagnosed acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) were randomized 1:1 to a digital health coach intervention or standard of care. The primary outcome of self-efficacy was measured by the Cancer Behavior Inventory (CBI) score. <b><i>Results:</i></b> A total of 147 patients (37 AML, 110 CLL) were enrolled from July 2020 to December 2022. In the AML cohort, there was a mean increase in CBI score of 7.03 in the digital health coaching arm compared to a mean decrease of −3.57 in the control arm at 30 days (<i>p</i> = 0.219). There were no significant associations between the intervention and other patient-reported outcomes for patients with CLL. <b><i>Conclusion:</i></b> There were numerical, but not statistically significant increases in self-efficacy metrics in AML patients who received digital health coaching. Although this trial was underpowered due to enrollment limitations during a pandemic, digital health coaching may provide benefit to patients with hematologic malignancy and warrants further investigation.