Ganglion Cell Complex Parameters in Primary Angle Closure Suspects

Abstract

<b><i>Introduction:</i></b> This study aimed to investigate the ganglion cell complex (GCC) parameters in primary angle closure suspects (PACS) and identify the related factors. <b><i>Methods:</i></b> A total of 731 subjects, including 289 subjects with PACS and 442 subjects without PACS, underwent RTVue XR OCT. GCC parameters were compared between the two groups. The linear mixed-effects model was performed to evaluate the relationships between the GCC parameters and related factors. <b><i>Results:</i></b> Significant differences were found in gender, age, spherical refractive error, height, waist, anterior chamber depth, lens thickness, axial length, superior GCC thickness, ganglion cell complex focal loss volume, ganglion cell complex global loss volume, and ganglion cell complex root mean square between PACS and normal controls. The linear mixed-effects model showed that age (<i>p</i> = 0.008) and blood glucose (<i>p</i> = 0.001) were negatively correlated with average GCC thickness in PACS subjects, and PACS (<i>p</i> = 0.036) and age (<i>p</i> &#x3c; 0.001) were the key influencing factors for average GCC thickness. <b><i>Conclusion:</i></b> GCC parameters in PACS subjects are different from those in normal controls. Careful explanation should be considered when evaluating changes of GCC parameters in patients with PACD.