Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis-Reference-Cited by-同舟云学术

Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis

Published:2021 Issue:1-2 Volume:66 Page:33-37
ISSN:0009-3157
Container-title:Chemotherapy
language:en
Short-container-title:Chemotherapy

Author:

Benvenuto Domenico^ORCID,Benedetti Francesca^ORCID,Demir Ayse Banu,Ciccozzi Massimo,Zella Davide^ORCID

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy. Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID. Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein. Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.

Publisher

S. Karger AG

Subject

Infectious Diseases,Pharmacology (medical),Drug Discovery,Pharmacology,Oncology,General Medicine

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