Cohesin <b><i>RAD21</i></b> Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients

Abstract

<i>RAD21</i> plays multiple roles in numerous cancers. In breast cancer (BC), a high level of RAD21 correlates with poor disease outcomes and resistance to chemotherapy. However, data regarding <i>RAD21</i> promoter methylation in BC tissue and its correlation with clinical outcomes in patients with BC remain limited. Here, we investigated the clinicopathological features associated with the methylation status of <i>RAD21</i> in BC to figure out its possible role in pathogenesis and the formation of breast carcinogenesis. The methylation status of the <i>RAD21</i> gene was significantly associated with better clinical outcomes in patients with BC.