Risk Factors for Potential Drug-Drug Interactions in Patients on Chronic Peritoneal Dialysis

Abstract

<b><i>Introduction:</i></b> The prevalence of potential drug-drug interactions (pDDIs) is becoming a major safety concern, as it has been previously linked to a significant number of adverse drug events and could have serious consequences for patients, including death. This is especially relevant for patients with chronic renal failure, as they are particularly vulnerable to drug-drug interactions. The aim of this study was to evaluate the prevalence and associated factors of pDDIs in patients receiving chronic peritoneal dialysis. <b><i>Methods:</i></b> An observational, cross-sectional study was conducted on consecutive peritoneal dialysis patients attending four tertiary care hospitals for regular monthly examination. The primary outcome was the number of pDDIs identified using Lexicomp. Potential predictors were determined using multiple linear regression. <b><i>Results:</i></b> Total number of patients included in the study was 140. The results showed that pDDIs were highly prevalent, especially in patients who use antiarrhythmics (<i>p</i> = 0.001), have diabetes mellitus (<i>p</i> = 0.001), recently started peritoneal dialysis (<i>p</i> = 0.003), or have higher number of prescribed drugs (<i>p &lt;</i> 0.001). Number of prescribed drugs (<i>p</i> &lt; 0.001) remained a significant predictor of high-risk pDDIs in addition to the female gender (<i>p</i> = 0.043). <b><i>Conclusion:</i></b> Clinicians should be particularly cautious when prescribing multiple medications to high-risk patients, such as peritoneal dialysis patients, to mitigate the risk of drug-drug interactions and associated adverse health outcomes.