Stunning Response with Low-Dose Enzalutamide after Abiraterone Acetate Failure in a Patient Diagnosed with Metastatic Castration-Resistant Prostate Cancer: A Case Report

Author:

Rossi Luigi,Cimino Giuseppe,Gozzi Elisa,Sinjari Marsela,Brandi Martina,Ceddia Serena,Cosimati Antonella,Raimondi Lucrezia,Fontana Antonella,Filippi Luca,Bagni Oreste,Spinelli Gian Paolo

Abstract

We report a case of an elderly patient with metastatic castration-resistant prostate cancer, initially treated with abiraterone acetate (1,000 mg/day) combined with LH-RH antagonist, prednisone (10 mg/day), and zoledronic acid to manage bone metastases. In consideration of his poor performance status, radiological and biochemical progression of the disease, we decided to switch abiraterone to enzalutamide (160 mg/day). Due to adverse events, we reduced enzalutamide to a dose of 80 mg/day. Currently, the disease is under control despite the use of a low dose of enzalutamide.

Publisher

S. Karger AG

Subject

Oncology

Reference15 articles.

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