Screening for Open Spina Bifida in a Routine Clinical Setting at the First-Trimester Scan: A Prospective Multicentre Cohort Study-Reference-Cited by-同舟云学术

Screening for Open Spina Bifida in a Routine Clinical Setting at the First-Trimester Scan: A Prospective Multicentre Cohort Study

Published:2021-02-03 Issue: Volume: Page:1-7
ISSN:1015-3837
Container-title:Fetal Diagnosis and Therapy
language:en
Short-container-title:Fetal Diagn Ther

Author:

Tiechl Johanna,Abdel Azim Samira^ORCID,Leitner Katharina,Berger Astrid,Mutz-Dehbalaie Irene,Goebel Georg,Scheier Matthias^ORCID

Abstract

Objective: The aim of this study was to investigate the performance of screening for open spina bifida (OSB) integrated into the routine first-trimester screening. Method: This is a prospective multicentre study of 4,755 women undergoing first-trimester ultrasound scans over a 4-year period. Measurements of the brainstem (BS) diameter and brainstem-to-occipital-bone (BSOB) distance were performed. The cisterna magna (CM) was measured in the tilted axial view. Results: Pregnancy outcome data were available for 4,658 fetuses included in this study. There were 5 fetuses with OSB, and in all of them, the BS/BSOB ratio and the CM measurements were abnormal. The sensitivity and specificity of a BS/BSOB ratio >1 were 100%. The sensitivity of a CM width <5th centile was 100%, and the specificity was 95.1%. In 4.6% of cases, the BS/BSOB ratio was between the 95th percentile and 1. In 87.1% of these cases, the CM was normal, and 12.9% had a CM below the 5th percentile. Conclusion: Screening for OSB is feasible in routine first-trimester scans. The BS/BSOB ratio shows a very good sensitivity and specificity. In cases with near-normal values for the BS/BSOB ratio, the CM width might be helpful for further assessment.

Publisher

S. Karger AG

Subject

Obstetrics and Gynaecology,Radiology Nuclear Medicine and imaging,Embryology,General Medicine,Pediatrics, Perinatology, and Child Health

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