Autoimmune Thyroiditis Induced by <b><i>Bartonella henselae</i></b> (Cat-Scratch Disease) Might Be Reversible

Abstract

<b><i>Introduction:</i></b> <i>Bartonella henselae</i> infection leads to development of cat-scratch disease (CSD) but may also trigger of autoimmune thyroiditis (AIT). <b><i>Case Presentation:</i></b> We describe a 4-year-old boy with a severe fever of unknown etiology, disseminated neck lymphadenopathy, and a headache. Treatment with antibiotics was employed, but finally a left tonsillectomy, selective left lymphadenectomy, and immunophenotyping were performed to exclude lymphoma. Histologic examination excluded lymphoma but revealed CSD. IgG against <i>B</i>. <i>henselae</i> and <i>Bartonella quintana</i> was positive. A goiter was also found and positive anti-thyroid antibodies confirmed AIT. Two months later, the thyroid was not palpable, normal on ultrasound, and both anti-thyroid antibodies were negative. The full reversibility was documented, and 6-year follow-up showed that the patient remains disease free. <b><i>Conclusion:</i></b> This is the first report that AIT triggered by <i>B</i>. <i>henselae</i>/<i>B</i>. <i>qunitana</i> might be reversible if the pathogenetic factor is eliminated at an early stage of disease.